A. Flieger

Discovery of a synthetic small molecule targeting the central regulator of Salmonella pathogenicity

The paper identifies a synthetic small molecule, C26, that inhibits HilD, a key regulator of Salmonella secretion systems, thereby preventing bacterial invasion of host cells.

High density genomic surveillance and risk profiling of clinical Listeria monocytogenes subtypes in Germany, 2018-2021

The paper analyzes genomic data from Listeria monocytogenes isolates in Germany to identify virulent and hypovirulent clones and their epidemiological patterns.

Rapid enzymatic detection of Shigatoxin-producing E. coli using fluorescence-labeled oligonucleotide substrates

This paper develops a rapid method to detect Shigatoxin-producing E. coli by measuring Stx activity using fluorescent oligonucleotide substrates.

Structure-function relationships underpin disulfide loop cleavage-dependent activation of Legionella pneumophila lysophosholipase A PlaA

This study reveals the structural basis for the regulated activation and substrate preference of PlaA, a lysophospholipase in Legionella pneumophila, showing how disulfide loop cleavage enhances catalytic activity and substrate specificity.

Recent O-antigen diversification masks highly pathogenic STEC O104:H4

The paper identifies genomically similar, highly pathogenic STEC strains with diverse O-antigens, masking their potential risk due to rare serotypes.

NAD(H)-mediated tetramerization controls the activity of Legionella pneumophila phospholipase PlaB

This study identifies an NAD(H)-mediated tetramerization mechanism that regulates the activity and localization of the Legionella pneumophila phospholipase PlaB.

Population structure-guided profiling of antibiotic resistance patterns in clinical Listeria monocytogenes isolates from Germany identifies pbpB3 alleles associated with low levels of cephalosporin resistance

The paper analyzes antibiotic resistance in Listeria monocytogenes isolates from Germany, identifying pbpB3 alleles linked to reduced cephalosporin resistance.

Can genome-based analysis be the new gold-standard for routine Salmonella serotyping?

This study evaluates genome-based in silico serotyping for Salmonella using SeqSero and MLST, finding high concordance with classical serotyping but needing refinement for monophasic variants.

A patatin-like phospholipase is crucial for gametocyte induction in the malaria parasite Plasmodium falciparum

This study shows that PNPLA1 deficiency in Plasmodium falciparum impairs gametocyte induction by altering phospholipid levels and gene expression related to sexual commitment.