Human Cytomegalovirus Immediate-Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus
C.-C. Wu, X. Jiang, X.-Z. Wang, X.-J. Liu, X.-J. Li, B. Yang, H.-Q. Ye, T. Harwardt, M. Jiang, H.-M. Xia, W. Wang, W. J. Britt, C. Paulus, M. Nevels, M.-H. Luo
This study shows HCMV IE1 protein causes SOX2 loss in NPCs by trapping unphosphorylated STAT3 in the nucleus, leading to neurodevelopmental damage.
bioRxiv · Apr 25, 2018Microbiology