Cryo-EM structure of amyloid fibril formed by α-synuclein familial A53E mutation
L. Jiang, c. sun, k. zhou, P. DePaola, W. S. Shin, T. Hillyer, M. R. Sawaya, H. Zhou
The paper presents a cryo-EM structure of α-synuclein fibrils with the A53E mutation, showing structural differences that may affect aggregation kinetics and disease progression.
bioRxiv · Mar 11, 2022 · PreprintBiophysics