Early-Stage Identification and Avoidance of Antisense Oligonucleotides Causing Species-Specific Inflammatory Responses in Human Volunteers Peripheral Blood Mononuclear Cells
S. A. Burel, T. Machemer, B. F. Baker, T. J. Kwoh, S. Paz, H. Younis, S. P. Henry
The paper develops a PBMC assay to identify ASOs causing immune responses in humans, finding variability in donor responses and linking IL-6 induction to TLR9 activation.
bioRxiv · Oct 30, 2021Pharmacology & Toxicology