Author

S. P. Henry

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

S. A. Burel· 2 shared S. Paz· 2 shared T. Machemer· 2 shared A. J. Pollak· 1 shared B. F. Baker· 1 shared H. Younis· 1 shared P. Cauntay· 1 shared S. Damle· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 27 mutual co-author links

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2 shared papersPharmacology & Toxicology

S. A. Burel

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2 papers

Recent·Most cited

Mechanism Driven Early Stage Identification and Avoidance of Antisense Oligonucleotides Causing TRL9 Mediated Inflammatory Responses in Bjab cells

A. J. Pollak, P. Cauntay, T. Machemer, S. Paz, S. Damle, S. P. Henry, S. A. Burel

The paper develops and validates a high-throughput Bjab cell assay to identify proinflammatory PS-ASOs by measuring Ccl22 mRNA levels, showing it replicates hPBMC assay results and provides mechanistic insights.

bioRxiv · Dec 12, 2021 · PreprintPharmacology & Toxicology

Early-Stage Identification and Avoidance of Antisense Oligonucleotides Causing Species-Specific Inflammatory Responses in Human Volunteers Peripheral Blood Mononuclear Cells

S. A. Burel, T. Machemer, B. F. Baker, T. J. Kwoh, S. Paz, H. Younis, S. P. Henry

The paper develops a PBMC assay to identify ASOs causing immune responses in humans, finding variability in donor responses and linking IL-6 induction to TLR9 activation.

bioRxiv · Oct 30, 2021Pharmacology & Toxicology