Molecular basis and functional consequences of the interaction between the Base Excision Repair DNA glycosylase NEIL1 and RPA
R. A. Le Meur, T. J. Pecen, K. V. Le Meur, Z. D. Nagel, W. J. Chazin
This study identifies two molecular interaction points between NEIL1 and RPA using biophysical methods and shows that disrupting this interaction does not impair NEIL1's activity against oxidative DNA damage in vitro but reveals a role in nucleotide excision repair in vivo.
bioRxiv · May 11, 2021Biophysics