Author

T. Khazma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein structure prediction· 2 Organism:Arabidopsis· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

A. Yaron· 2 shared J. Guez-Haddad· 2 shared M. Hons· 2 shared R. Zalk· 2 shared Y. Opatowsky· 2 shared A. Grossman· 1 shared A. Plotnikov· 1 shared C. Mim· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

A. Yaron

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3 papers

Recent·Most cited

Disproportion among reticulon-like 16 (RTNLB16) splice variants disrupts growth and decreases sensitivity to ABA and senescence in Arabidopsis

T. Khazma, D. Levi, H. W. Ben-Asher, G. MIller

This study shows that imbalanced RTNLB16 splice variants in Arabidopsis cause growth defects and reduced sensitivity to abscisic acid and senescence.

bioRxiv · Dec 18, 2023 · PreprintPlant Biology

A Duplex Structure of SARM1 Octamers Induced by a New Inhibitor

T. Khazma, Y. Golan-Vaishenker, J. Guez-Haddad, A. Grossman, R. Sain, A. Plotnikov, R. Zalk, A. Yaron, M. Hons, Y. Opatowsky

The paper identifies a new inhibitor of SARM1 that stabilizes an octamer conformation and induces a meta-stable duplex structure, revealing an additional auto-inhibition mechanism.

bioRxiv · Mar 2, 2022 · PreprintBiochemistry

The Structural Basis for SARM1 Inhibition, and Activation Under Energetic Stress

M. Sporny, J. Guez-Haddad, T. Khazma, A. Yaron, M. Dessau, C. Mim, M. N. Isupov, R. Zalk, M. Hons, Y. Opatowsky

This paper presents cryo-EM structures of SARM1 showing how NAD+ inhibits its NADase activity and how NAD+ depletion activates it, leading to cell death.

bioRxiv · Aug 5, 2020Biochemistry