Kinase-modulated bioluminescent indicators enable noninvasive imaging of drug activity in the brain
Y. Wu, J. Walker, L. Ning, M. Westberg, M. Monje, T. Kirkland, M. Lin, Y. Su
This paper introduces KiMBIs, bioluminescent indicators that enable non-invasive imaging of kinase inhibitor activity in the brain, identifying temuterkib as a promising brain-active ERK inhibitor.
bioRxiv · Dec 30, 2022Pharmacology & Toxicology