The TFIID subunit Taf4 is required for pancreatic beta cell function and identity.
T. Kleiber, G. Davidson, G. Mengus, I. Martianov, I. Davidson
This study shows that Taf4 inactivation in pancreatic beta cells causes functional defects and chromatin remodeling, leading to cell identity changes and trans-differentiation into alpha-like cells.
bioRxiv · May 23, 2020 · PreprintCell Biology