Identification of Small Molecule Modulators of Diguanylate Cyclase by FRET-based High-Throughput-Screening
M. Christen, C. Kamischke, H. D. Kulasekara, K. C. Olivas, B. R. Kulasekara, B. Christen, T. Kline, S. I. Miller
This study identifies small molecule modulators of the diguanylate cyclase DgcA using FRET-based screening and structure-activity analysis, revealing diverse chemical scaffolds with inhibitory or activating effects.
bioRxiv · Aug 28, 2018Biochemistry