The contribution of PARP1, PARP2 and poly(ADP-ribosyl)ation to base excision repair in the nucleosomal context
M. Kutuzov, E. Belousova, T. Kurgina, A. Ukraintsev, I. Vasil'eva, S. Khodyreva, O. Lavrik
This study examines how PARP1 and PARP2 regulate BER enzymes in the nucleosomal context, finding PARP1 suppresses enzyme activity while PARP2 affects DNA sealing and modulates Pol{beta} and LigIII.
bioRxiv · Oct 5, 2020Biochemistry