The PAR2 signal peptide prevents premature receptor cleavage and activation
B. Liu, G. Lee, J. Wu, J. Deming, C. Kuei, A. Harrington, L. Wang, J. Towne, T. Lovenberg, C. Liu, S. Sun
This study shows that the PAR2 signal peptide prevents premature receptor cleavage and activation by intracellular proteases, ensuring proper cell surface expression and ligand response.
bioRxiv · Sep 6, 2019Biochemistry