A decoy heterotrimeric Gα protein has substantially reduced nucleotide binding but retains nucleotide-independent interactions with its cognate RGS protein and Gβγ dimer
F. Lou, T. M. Abramyan, H. Jia, A. Tropsha, A. M. Jones
This paper shows that Arabidopsis XLG2 has reduced nucleotide binding but maintains interactions with RGS and Gβγ, suggesting it functions as a dominant negative G protein.
bioRxiv · Oct 6, 2019Biochemistry