H. Jia

FLASH Irradiation Regulates IFN-β induction by mtDNA via Cytochrome c Leakage

This study shows FLASH irradiation increases cytochrome c leakage from mitochondria in normal cells, reducing mtDNA accumulation and IFN-β secretion, while having the opposite effect in cancer cells.

Evaluation of the effects of ripening-related genes on fruit metabolites and the associated regulatory mechanisms in tomato

The paper evaluates the effects of ripening-related genes on tomato fruit metabolites and identifies regulatory mechanisms, showing that HY5 mutation increases fructose and glucose levels by modulating SWEET12c expression.

Genomic Revisitation and Reclassification of the Genus Providencia

This study reclassifies Providencia species using genomic data, identifies a new species, and reveals high antibiotic resistance gene prevalence.

Nifuroxazide Suppresses PD-L1 Expression and Enhances the Efficacy of Radiotherapy in Hepatocellular Carcinoma

This study shows nifuroxazide enhances radiotherapy in HCC by reducing PD-L1 expression and improving tumor response.

Co-engagement of TIGIT+ immune cells to PD-L1+ tumours by a bispecific antibody potentiates T-cell response and tumour control

This paper shows that a bispecific antibody targeting PD-L1 and TIGIT enhances T-cell response and tumor control compared to using the individual antibodies.

Ketone-loading as A Novel Sports Nutrition Strategy: Chronic Ketone Supplementation Elicits Further Favorable Metabolic Changes in Keto-adapted Mice

This study shows that chronic exogenous ketone body administration in keto-adapted mice increases circulating ketone bodies and enhances gene expression related to fatty acid oxidation and energy homeostasis.

Identifying keystone species in microbial communities using deep learning

This paper introduces a deep learning framework to identify keystone species in microbial communities using synthetic and real microbiome data, finding taxa with high keystoneness show community specificity.

A proximity-dependent biotinylation map of cytosol-facing organelle outer membrane proteome in living Arabidopsis cells

The paper develops an OM proximity labeling system to map the proteome of cytosol-facing outer membranes in Arabidopsis cells and identifies potential receptors for protein translocation and organelle communication.

Efficient transgene-free genome editing in plants in the T0 generation based on a co-editing strategy

This study develops a co-editing strategy to generate transgene-free, gene-edited plants in the T0 generation using Agrobacterium-mediated transient expression of CBE/gRNA and Cas12a/crRNA-GFP.

Perturbation of mitochondrial Ca2+ homeostasis activates cross-compartmental proteostatic response in Arabidopsis

This study shows that disrupting mitochondrial Ca2+ homeostasis in Arabidopsis leads to misregulated gene expression and proteostatic responses, affecting plant growth and stress resistance.

ID1 functions as an autonomous phosphate (Pi) regulator upstream of the miR399-ZmPHO2 signaling module in maize

The paper identifies ID1 as an autonomous phosphate regulator that modulates the miR399-ZmPHO2 signaling module to maintain Pi homeostasis in maize.

Emerging Evidence for Poxvirus-Mediated Unfolded Protein Response: Lumpy Skin Disease Virus Maintains Self-replication by Activating PERK and IRE1

This study shows that lumpy skin disease virus activates PERK and IRE1 pathways to support its replication, suggesting potential therapeutic targets for poxvirus infections.

Sex differences in the nasal microbiome of healthy young adults

This study analyzes the nasal microbiome of healthy young adults, revealing sex-specific differences in composition and ecological stability between males and females.

A Unified Catalog of 19,251 Non-human Reference Species Genomes Provides New Insights into the Mammalian Gut Microbiomes

The paper catalogs 19,251 non-human reference genomes from Qinghai-Tibetan Plateau animals, revealing new insights into mammalian gut microbiome diversity and host-microbe interactions.

Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation.

This study compares cytokine levels in mothers and infants with and without maternal SARS-CoV-2 infection, finding elevated IL-6, IP-10, and IL-8 in both groups.

Extraction, purification and anti-TMV effects of α (β)-2,7,11-cembratriene-4,6-diol from tobacco leaves

This study extracts and purifies β-2,7,11-cembratriene-4,6-diol from tobacco leaves and demonstrates its antiviral activity against TMV through in vivo and molecular assays.

Acute SARS-CoV-2 infection in pregnancy is associated with placental ACE-2 shedding

This study examines ACE-2 expression and shedding in placental tissues and maternal serum during SARS-CoV-2 infection in pregnancy, finding increased soluble ACE-2 in third-trimester infections.

Individual differences in members of Actinobacteria, Bacteroidetes, and Firmicutes is associated with resistance or vulnerability to addiction-like behaviors in heterogeneous stock rats

The paper identifies microbiome composition and metabolic pathways associated with resistance or vulnerability to addiction-like behaviors in rats using a large cohort and extended cocaine self-administration.

Direct molecular evidence for an ancient, conserved developmental toolkit controlling post-transcriptional gene regulation in land plants

This study identifies an ancient and conserved HYL1-DCL1 interaction critical for miRNA production and plant development, showing its evolutionary origin predates moss-seed plant divergence.

The secreted peptide IRP functions as a DAMP in rice immunity

The paper identifies IRP as a DAMP in rice immunity, showing it activates MAPKs and OsWRKYs to amplify chitin signaling.

Kinetic and structural mechanism for DNA unwinding by a non-hexameric helicase

This study investigates the DNA unwinding mechanism of UvrD, a non-hexameric helicase, revealing a stepwise translocation with variable base pair steps and strand sequestration.

Sequencing of clinical samples reveals that adaptation keeps establishing during H7N9 virus infection in humans

This study analyzes H7N9 virus genome mutations in human clinical samples to identify potential adaptations during infection.

The female urinary microbiota in relation to the reproductive tract microbiota

The study analyzes the urinary microbiota of 147 Chinese women, revealing non-sterile urine with distinct bacterial communities and showing similarity to cervical and uterine microbiota rather than vaginal microbiota.

Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity

The paper examines age-related changes in ACE2 expression and apoptosis regulation in lung tissue, linking these to differences in COVID-19 severity across age groups.

Personalized vagino-cervical microbiome dynamics after oral probiotics

The study tracks vagino-cervical microbiome changes in 60 women over a year after oral probiotics, finding no colonization but stability in Lactobacillus-dominated communities and potential benefits for some individuals.

Shotgun Metagenomics of 361 elderly women reveals gut microbiome change in bone mass loss

This study analyzes gut microbiome data from 361 elderly women to explore its association with bone mass loss and bone mineral density.

HflX controls hypoxia-induced non-replicating persistence in slow growing mycobacteria

This study shows HflX in slow-growing mycobacteria enables hypoxia-induced non-replicating persistence, contributing to drug tolerance and dormancy.

The YdiU Domain Modulates Bacterial Stress Signaling through Mn2+-dependent UMPylation

This paper identifies YdiU as a Mn2+-dependent UMPylase in Salmonella that modulates chaperone function through UMPylation, enhancing stress resistance.

A multi-omic cohort as a reference point for promoting a healthy human gut microbiome

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

Over 50000 metagenomically assembled draft genomes for the human oral microbiome reveal new taxa

The paper assembles over 56,000 metagenome-assembled genomes from oral microbiome samples, revealing new taxa and biomarkers for diseases.