Targeting the water network in cyclin G associated kinase (GAK) with 4-anilino-quin(az)oline inhibitors
C. R. M. Asquith, G. J. Tizzard, J. M. Bennett, C. I. Wells, J. M. Elkins, T. M. M. Willson, A. Poso, T. Laitinen
This paper designs and tests 4-anilinoquinoline inhibitors targeting cyclin G-associated kinase (GAK) by analyzing water networks in the ATP binding site.
bioRxiv · Mar 6, 2020Biochemistry