Author

J. M. Elkins

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Pharmacology & Toxicology· 3 Cell Biology· 1 Immunology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 7 Approach:experimental assay· 7 Organism:human· 3 Approach:statistical model· 2 Organism:Arabidopsis· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1

Frequent Co-Authors

C. I. Wells· 6 shared C. R. M. Asquith· 5 shared J. M. Bennett· 5 shared W. J. Zuercher· 5 shared T. M. Willson· 4 shared D. H. Drewry· 3 shared G. J. Tizzard· 3 shared P. H. Godoi· 3 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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6 shared papersBiochemistry

C. I. Wells

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Resident Synovial Macrophages in Synovial Fluid: Implications for Immunoregulation in Infectious and Inflammatory Arthritis

K. I. Cyndari, B. M. I. Scorza, Z. R. Zacharias, L. Strand, K. Mahachi, J. M. Oviedo, L. Gibbs, D. Pessoa-Pereira, G. Ausdal, D. Hendricks, R. Yahashiri, J. M. Elkins, T. Gulbrandsen, A. R. Peterson, M. C. Willey, , C. A. A. Petersen

The paper identifies resident synovial macrophages in synovial fluid using flow cytometry and scRNA-seq, showing their migratory ability and functional roles in both infectious and inflammatory arthritis.

bioRxiv · Sep 29, 2023 · PreprintImmunology

An open source plant kinase chemogenomics set

M. F. Ercoli, P. Zonzini Ramos, R. Jain, J. Pilotte, O. X. Dong, T. Thompson, C. I. Wells, J. M. Elkins, A. M. Edwards, R. M. Counago, D. H. Drewry, P. C. Ronald

The paper presents a plant kinase chemogenomics set, identifying compounds that affect root development in Arabidopsis and rice, with implications for understanding plant kinase function.

bioRxiv · Jun 18, 2022Plant Biology

Targeting the water network in cyclin G associated kinase (GAK) with 4-anilino-quin(az)oline inhibitors

C. R. M. Asquith, G. J. Tizzard, J. M. Bennett, C. I. Wells, J. M. Elkins, T. M. M. Willson, A. Poso, T. Laitinen

This paper designs and tests 4-anilinoquinoline inhibitors targeting cyclin G-associated kinase (GAK) by analyzing water networks in the ATP binding site.

bioRxiv · Mar 6, 2020Biochemistry

Design and analysis of the 4-anilino-quin(az)oline kinase inhibition profiles of GAK/SLK/STK10 using quantitative structure activity relationships

C. R. M. Asquith, T. Laitinen, J. M. Bennett, C. I. Wells, J. M. Elkins, W. J. Zuercher, G. J. Tizzard, A. Poso

The paper designs and synthesizes 4-anilino-quin(az)oline compounds to analyze their kinase inhibition profiles and structure-activity relationships for GAK/SLK/STK10 targets.

bioRxiv · Sep 5, 2019Biochemistry

Development of SGC-GAK-1 as an orally active in vivo probe for cyclin G associated kinase through cytochrome P450 inhibition

C. R. M. Asquith, J. M. Bennett, L. Su, T. Latinen, J. M. Elkins, J. E. Pickett, C. I. Wells, Z. Li, T. M. Willson, W. J. Zuercher

The paper develops SGC-GAK-1 as an orally active in vivo probe for GAK by using cytochrome P450 inhibition to improve its metabolic stability and plasma exposure.

bioRxiv · May 7, 2019 · PreprintPharmacology & Toxicology

Structural and binding studies of human CAMKK2 kinase domain bound to small molecule ligands

G. S. Profeta, C. V. dos Reis, P. H. Godoi, A. M. Fala, R. Satori, A. P. Salmazo, P. Z. Ramos, K. B. Massirer, J. M. Elkins, D. H. Drewry, O. Gileadi, R. M. Counago

This study presents six novel co-structures of CAMKK2 bound to small molecule ligands and shows some ligand binding is enthalpy driven.

bioRxiv · Feb 1, 2019 · PreprintBiochemistry

SGC-GAK-1: a chemical probe for cyclin G associated kinase (GAK)

C. R. M. Asquith, B.-T. Berger, J. Wan, J. M. Bennett, M. P. East, J. M. Elkins, O. Fedorov, P. H. Godoi, D. M. Hunter, S. Knapp, S. Mueller, C. I. Wells, H. S. Earp, T. M. Willson, W. J. Zuercher

The paper describes SGC-GAK-1, a selective GAK inhibitor, and identifies a related compound that inhibits RIPK2 without GAK activity, providing tools to study GAK and RIPK2 biology.

bioRxiv · Jul 25, 2018Cell Biology

Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase

C. R. M. Asquith, T. Laitinen, J. M. Bennett, P. H. Godoi, G. J. Tizzard, J. M. Elkins, T. M. Willson, W. J. Zuercher

The paper identifies 4-anilinoquinolines as potent GAK inhibitors with high selectivity and suggests their potential as tools for studying GAK's role in infectious diseases.

bioRxiv · Apr 11, 2017Pharmacology & Toxicology

Progress Towards a Public Chemogenomic Set for Protein Kinases and a Call for Contributions

D. H. Drewry, C. I. Wells, D. M. Andrews, R. Angell, H. Al-Ali, A. D. Axtman, S. J. Capuzzi, J. M. Elkins, P. Ettmayer, M. Frederiksen, O. Gileadi, N. Gray, A. Hooper, S. Knapp, S. Laufer, , T. M. Willson

The paper shares progress on a kinase chemogenomic set, releases inhibitor profiling data, and calls for community collaboration to complete the set.

bioRxiv · Jan 31, 2017Pharmacology & Toxicology