The gradient-based parameter optimization to determine membrane ionic current composition of human induced pluripotent stem cell-derived cardiomyocytes
H. Kohjitani, S. Koda, Y. Himeno, T. Makiyama, Y. Yamamoto, D. Yoshinaga, Y. Wuriyanghai, A. Kashiwa, F. Toyoda, Y. Zhang, A. Amano, A. Noma, T. Kimura
The paper develops a gradient-based optimization method to recover ionic current conductances from action potentials of hiPSC-CMs, showing convergence to the original parameter values.
bioRxiv · May 16, 2022 · PreprintPhysiology