Y. Yamamoto

Label-free imaging of intracellular structures in living mammalian cells via external apodization phase-contrast microscopy

This study introduces ExAPC microscopy for label-free visualization of intracellular structures, showing its ability to resolve biomolecular condensates, lipid droplets, and mitochondria with high spatiotemporal resolution.

How to control unpredictable others in court-net sports

The paper examines strategies in court net sports to control unpredictable behavior, finding skilled players use regularity to disrupt expectations and promote cooperation.

Overcoming antibody-resistant SARS-CoV-2 variants with bispecific antibodies constructed using non-neutralizing antibodies

This study develops bispecific antibodies that restore effectiveness against SARS-CoV-2 variants resistant to existing antibodies by combining non-neutralizing antibodies targeting different epitopes.

Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant

The paper investigates the virological features of the SARS-CoV-2 EG.5.1 variant, finding its fitness and antiviral sensitivity comparable to XBB.1.5, with structural differences in spike proteins.

Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

This study identifies XBB as a SARS-CoV-2 variant resulting from recombination of BA.2 subvariants, showing increased resistance to neutralizing antibodies and enhanced fusogenicity compared to BA.2.75.

Convergent evolution of the SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

The paper investigates convergent evolution in SARS-CoV-2 Omicron subvariants, identifying five critical spike protein substitutions in BQ.1.1 that enhance viral fitness and antibody resistance.

Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5

This study compares the pathogenicity of SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.5, finding BA.5 is more fusogenic and induces stronger inflammation than earlier variants.

Virological characteristics of the SARS-CoV-2 Omicron BA.2.75

This study investigates the virological characteristics of SARS-CoV-2 Omicron BA.2.75, finding it has higher transmissibility and pathogenicity compared to BA.2 and BA.5, but similar sensitivity to antiviral drugs.

Virological characteristics of the novel SARS-CoV-2 Omicron variants including BA.2.12.1, BA.4 and BA.5

This study analyzes the virological characteristics of SARS-CoV-2 Omicron variants BA.2.12.1, BA.4, and BA.5, finding they have higher reproduction numbers, reduced neutralization by prior immunity, increased replication in lung cells, and greater pathogenicity in hamsters compared to BA.2.

The gradient-based parameter optimization to determine membrane ionic current composition of human induced pluripotent stem cell-derived cardiomyocytes

The paper develops a gradient-based optimization method to recover ionic current conductances from action potentials of hiPSC-CMs, showing convergence to the original parameter values.

Aberrant regulation of serine metabolism drives extracellular vesicle release and cancer progression

This study identifies miR-891b and PSAT1 as regulators of EV secretion and cancer progression through the serine-ceramide pathway.

Screening of the optimal CpG-oligodeoxynucleotide for anti-inflammatory responses in avian macrophage cell line HD11

This study evaluates the anti-inflammatory effects of five CpG-ODN in chick macrophages, finding that CpG-C2395 significantly reduces inflammation-related gene expression.

LAG3 regulates antibody responses in a murine model of kidney transplantation

This study shows that LAG3 deficiency in mice leads to rapid rejection of kidney allografts via antibody-mediated rejection, highlighting LAG3's role in regulating anti-donor humoral immunity.

Expressional Diversity and Cancer-prone Phenotypes in Cigarette-smoking Lungs at Single Cell Resolution

This study uses scMeta-analysis to integrate public scRNA-seq data from smoking lungs, revealing expressional diversity and aging-related gene expression differences linked to smoking-induced carcinogenesis.

Inferring the Demographic History of Japanese Eel (Anguilla japonica) from Genomic Data: Insights for Conservation and Fisheries Management

This study infers the demographic history of Japanese eel using genomic data, revealing population bottlenecks and growth periods linked to environmental changes.

Identification of two cancer stem cell-like populations in triple-negative breast cancer xenografts

The paper identifies two cancer stem cell-like populations in TNBC xenografts using transcriptomic analysis and confirms their presence in patient data, suggesting potential as biomarkers and implications for drug resistance.

Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain

This study identifies novel GPR85 inverse-agonists with IC50 values around 1 µM and shows they modulate potassium channel opening in cerebellar Purkinje cells.

A novel hamster model of SARS-CoV-2 respiratory infection using a pseudotyped virus

This paper develops a hamster model of SARS-CoV-2 infection using a pseudotyped virus, showing dose-dependent luminescence in the lungs.

Aberrant accumulation of NIK promotes tumorigenicity by dysregulating post-translational modifications in breast cancer

This study identifies NIK upregulation in breast cancer due to translational dysregulation, which promotes tumorigenicity by activating the non-canonical NF-κB pathway.

Visualizing looping of two endogenous genomic loci using synthetic zinc-finger proteins with anti-FLAG and anti-HA frankenbodies in living cells

The paper introduces a method to visualize two endogenous chromatin loci in living cells using synthetic zinc-finger proteins and frankenbodies, revealing their dynamic association and separation upon cohesin disruption.

The plot thickens: haploid and triploid-like thalli, hybridization, and biased mating type ratios in Letharia

The paper investigates the reproductive biology of Letharia fungi, finding haploidy in some specimens and triploid-like features in others, suggesting hybridization and asexual reproduction in certain regions.

Evaluation of SARS-CoV-2 neutralizing antibodies using a vesicular stomatitis virus possessing SARS-CoV-2 spike protein

This study evaluates SARS-CoV-2 neutralizing antibodies using a pseudotyped virus assay and compares results with immunofluorescence assay findings.

Pivotal involvement of the CX3CL1-CX3CR1 axis for the recruitment of M2-TAMs in skin carcinogenesis

The paper investigates the role of the CX3CL1-CX3CR1 axis in skin carcinogenesis, finding that it promotes tumor-associated macrophage recruitment and function, contributing to cancer progression.

miR-26a regulates extracellular vesicle secretion from prostate cancer cells via targeting SHC4, PFDN4 and CHORDC1

This study identifies miR-26a as a regulator of extracellular vesicle secretion in prostate cancer cells by targeting SHC4, PFDN4, and CHORDC1, which inhibits tumor progression.