Membrane-embedded polar residues target membrane proteins for degradation by the quality control protease FtsH
M. Chai-Danino, N. Ravensary, T. Onyshchuk, M. Plohn, A. B. D. Barshap, A. Bsoul, H. Peled-Zehavi, N. Fluman
The paper identifies how lipid-facing polar residues direct membrane proteins to FtsH-mediated degradation in E. coli, revealing a mechanism for recognizing misfolded proteins.
bioRxiv · Dec 12, 2023Biochemistry