Single-molecule Dynamic In-Solution Inhibition Assay: A Method for Full Kinetic Profiling of Drug Candidate Binding to GPCRs in Native Membranes
T. P. Kaminski, V. P. Zhdanov, F. Hook
The paper introduces a method to profile drug binding kinetics to GPCRs in native membranes using single-molecule imaging, demonstrating its application with beta2AR and drug candidates.
bioRxiv · Sep 16, 2021 · PreprintBiophysics