In vivo magnetic resonance spectroscopy of hyperpolarized pyruvate in a male guinea pig model of life-long Western diet consumption and non-alcoholic fatty liver disease development
L. M. Smith, C. B. Pitts, L. J. Friesen-Waldner, N. H. Prabhu, K. E. Mathers, K. J. Sinclair, T. P. Wade, T. R. Regnault, C. A. McKenzie
This study uses hyperpolarized MRS and MRI to examine how a lifelong Western diet affects liver metabolism and NAFLD in guinea pigs, finding increased fat deposition and shifts in metabolic pathways.
bioRxiv · Feb 5, 2021Biophysics