Essentiality of c-di-AMP in Bacillus subtilis: Bypassing mutations converge in potassium and glutamate homeostasis
L. Krüger, C. Herzberg, H. Rath, T. Pedreira, A. Poehlein, J. Gundlach, R. Daniel, U. Völker, U. Mäder, J. Stülke
This paper identifies suppressor mutations in Bacillus subtilis that allow growth of a c-di-AMP-free strain under toxic conditions, revealing the role of potassium and glutamate homeostasis in c-di-AMP essentiality.
bioRxiv · Sep 3, 2020Microbiology