A. Poehlein

Novel insights into phage biology of the pathogen Clostridioides difficile based on the active virome

This study identifies active phages in C. difficile strains under natural stress conditions and discovers novel phage-mediated DNA transfer mechanisms.

A patchwork pathway of apparently recent origin enables degradation of the synthetic buffer compound TRIS in bacteria

The paper discovers a recently evolved bacterial pathway for degrading TRIS, a synthetic buffer, through horizontal gene transfer and shows its global distribution.

The previously uncharacterized RnpM (YlxR) protein modulates the activity of ribonuclease P in Bacillus subtilis

The paper identifies RnpM (YlxR) as a novel modulator of RNase P activity in B. subtilis, reducing its ability to process pre-tRNAs.

Direct and culture-independent detection of low-abundant Clostridioides difficile in environmental DNA via PCR

This paper develops a PCR method to detect low-abundant Clostridioides difficile in environmental samples, revealing biases in strain isolation due to antibiotic-based enrichment.

Pan-genome analysis of six complete Paracoccus type strain genomes from hybrid next generation sequencing

This study analyzes six complete Paracoccus genomes to understand genomic adaptation and diversity across ecological niches.

SUB-OPTIMAL ENVIRONMENTAL CONDITIONS PROLONG PHAGE EPIDEMICS IN BACTERIAL POPULATIONS

The paper shows that suboptimal environmental conditions slow phage resistance evolution in bacteria, prolonging phage epidemics and potentially increasing the persistence of virulent phages.

New Microviridae isolated from Sulfitobacter reveals two cosmopolitan subfamilies of ssDNA phages infecting marine and terrestrial Alphaproteobacteria

The paper isolates a new Microviridae phage and identifies two new subfamilies of ssDNA phages infecting Alphaproteobacteria, showing their cosmopolitan distribution.

The Bacillus phage SPβ and its relatives: A temperate phage model system reveals new strains, species, prophage integration loci, conserved proteins and lysogeny management components

The paper identifies new SPβ phage strains, integration loci, and prophage features, revealing conserved genes and lysogeny management components in Bacillus phages.

Higher phage virulence accelerates the evolution of host resistance

The paper experiments with phage virulence and shows that higher virulence accelerates host resistance evolution, leading to faster phage extinction.

Nitrogen availability drives gene length of dominant prokaryotes and diversity of genes acquiring Nitrogen-species in oceanic systems

The paper shows that nitrogen availability affects gene length and diversity of nitrogen-acquiring genes in oceanic prokaryotes.

Essentiality of c-di-AMP in Bacillus subtilis: Bypassing mutations converge in potassium and glutamate homeostasis

This paper identifies suppressor mutations in Bacillus subtilis that allow growth of a c-di-AMP-free strain under toxic conditions, revealing the role of potassium and glutamate homeostasis in c-di-AMP essentiality.

Quasi-essentiality of RNase Y in Bacillus subtilis is caused by its critical role in the control of mRNA homeostasis

This study shows that RNase Y is quasi-essential in Bacillus subtilis due to its role in mRNA homeostasis, as suppressor mutations in RNA polymerase subunits alleviate its deletion effects.

Resistance to serine in Bacillus subtilis: Identification of the serine transporter YbeC and of a metabolic network that links serine and threonine metabolism

This study identifies YbeC as the major serine transporter in Bacillus subtilis and reveals a metabolic link between serine and threonine that causes serine toxicity.

Unravelling native plant resistomes - The Sphagnum microbiome harbours versatile and novel antimicrobial resistance genes

The paper identifies a diverse and novel set of antimicrobial resistance genes in the Sphagnum microbiome, highlighting its ecological role in bog ecosystems.