HDAC6 promotes self-renewal and migration/invasion of rhabdomyosarcoma
E. Chen, T. Q. Pham, K. Robinson, L. Xu, S. X. Skapek
This study identifies HDAC6 as a driver of RMS tumor growth, self-renewal, and migration/invasion, with RAC1 as a key mediator, suggesting targeting the HDAC6-RAC1 axis as a therapeutic strategy.
bioRxiv · Oct 30, 2019 · PreprintCancer Biology