An Exon Skipping Screen Identifies Antitumor Drugs That Are Potent Modulators of Pre-mRNA Splicing, Suggesting New Therapeutic Applications
Y. Shi, W. Bray, A. J. Smith, W. Zhou, J. Calaoagan, C. Lagisetti, L. Sambucetti, P. Crews, R. S. Lokey, T. R. Webb
The paper identifies antitumor drugs that modulate pre-mRNA splicing through a screening assay, revealing new therapeutic applications and SF3B1 antagonists.
bioRxiv · Mar 21, 2019Cancer Biology