Structural characterization of an intermediate reveals a unified mechanism for the CLC Cl-/H+ transport cycle
T. S. Chavan, R. C. Cheng, T. Jiang, I. I. Mathews, R. A. Stein, A. Koehl, H. S. Mchaourab, E. Tajkhorshid, M. Maduke
The paper presents a 2.6 Å structure of a CLC mutant, revealing a global conformational change that supports a unified transport mechanism for CLC proteins.
bioRxiv · Nov 27, 2019Biophysics