Author

T. Schwabe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:statistical model· 3 Assay:electrophysiology· 2 Approach:experimental assay· 2 Assay:fluorescence / live-cell microscopy· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

K. Benndorf· 3 shared C. Sattler· 2 shared H. Gohlke· 2 shared J. Kusch· 2 shared M. Kondapuram· 2 shared R. Schmauder· 2 shared A. Schweinitz· 1 shared B. Frieg· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersBiophysics

K. Benndorf

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3 papers

Recent·Most cited

cAMP binding to closed pacemaker ion channels is cooperative

S. Kuschke, S. Thon, T. Schwabe, K. Benndorf, R. Schmauder

This study demonstrates cooperative cAMP binding to resting HCN2 channels in native membranes using single-molecule fluorescence techniques, showing cooperativity precedes channel activation.

bioRxiv · Apr 18, 2023Biophysics

Functional and structural characterization of interactions between opposite subunits in HCN pacemaker channels

M. Kondapuram, B. Frieg, S. Yueksel, T. Schwabe, C. Sattler, M. Lelle, A. Schweinitz, R. Schmauder, K. Benndorf, H. Gohlke, J. Kusch

The paper identifies residue K464 in the C-linker of HCN2 channels as critical for stabilizing the closed state through interactions with opposite subunits, supported by mutagenesis, electrophysiology, and molecular dynamics simulations.

bioRxiv · Sep 21, 2020Biophysics

Pathways of inter- and intrasubunit allosteric signaling in the C-linker disk and cyclic nucleotide-binding domain of HCN2 channels

C. Pfleger, J. Kusch, M. Kondapuram, T. Schwabe, C. Sattler, K. Benndorf, H. Gohlke

The paper identifies inter- and intrasubunit allosteric signaling pathways in HCN2 channels through structural dynamics analysis and experimental validation.

bioRxiv · Jun 13, 2020Biophysics