Structural visualisation of the dynamics of DNA unwinding by a replicative helicase
T. Shahid, M. Tehseen, L. Alhudhali, A. R. Clark, C. G. Savva, S. M. Hamdan, A. De Biasio
This study uses cryo-EM to visualize the dynamics of DNA unwinding by the SV40 Large Tumor Antigen helicase, revealing how ATP hydrolysis drives translocation and strand separation.
bioRxiv · Apr 19, 2024 · PreprintBiophysics