A. R. Clark

Discrete and conserved inflammatory signatures drive thrombosis in different organs after Salmonella infection

This study identifies discrete inflammatory signatures driving thrombosis in the spleen and liver after Salmonella infection, revealing both organ-specific and shared mechanisms.

The glucocorticoid dexamethasone inhibits HIF-1alpha stabilisation and metabolic reprogramming in lipopolysaccharide-stimulated primary macrophages.

This study shows dexamethasone inhibits HIF-1α stabilization and reduces GLUT1 expression in lipopolysaccharide-stimulated macrophages, impairing glucose uptake and metabolic reprogramming.

The glucocorticoid dexamethasone impairs the expression of anti-viral mediators in activated macrophages by inhibiting both expression and function of interferon beta.

This study shows dexamethasone inhibits antiviral gene expression in macrophages by suppressing IFNβ expression and downstream interferon-regulated genes.

Multi-scale modelling of shear stress on the syncytiotrophoblast: Could maternal blood flow impact placental function across gestation?

This study identifies shear-sensing proteins in syncytiotrophoblast and models shear stress changes across gestation, suggesting early pregnancy mechanical stimuli influence placental development.

Single cell transcriptomics reveal disrupted kidney filter cell-cell interactions after early and selective podocyte injury

The paper uses single-cell RNA sequencing to identify early transcriptional changes in kidney cells after podocyte injury, revealing disrupted cell-cell interactions that contribute to chronic kidney disease progression.