Author

C. G. Savva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Ancelin· 1 shared A. Barducci· 1 shared A. Boulahtouf· 1 shared A. D. Cameron· 1 shared A. De Biasio· 1 shared C. Bechara· 1 shared D. H. Brotherton· 1 shared E. A. Brown· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiochemistry

A. Ancelin

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO2

D. H. Brotherton, S. Nijjar, C. G. Savva, N. Dale, A. D. Cameron

The paper shows that mutating K125 in Cx26 to glutamate mimics CO2 regulation, causing gap junctions to remain closed, and reveals structural changes in Cx26 that explain this regulation.

eLife · Jun 3, 2024Peer-reviewedBiochemistry

Structure of Aquifex aeolicus Lumazine Synthase by Cryo-Electron Microscopy to 1.42 Angstrom Resolution

C. G. Savva, M. A. Sobhy, A. De Biasio, S. M. Hamdan

The paper uses Cryo-EM to determine the structure of Aquifex aeolicus lumazine synthase at 1.42 Angstrom resolution, revealing hydrogen atoms and confirming near-atomic resolution for protein complexes.

bioRxiv · Mar 21, 2024 · PreprintBiophysics

Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex

J. Gruszczyk, L. Grandvuillemin, J. Lai-Kee-Him, M. Paloni, C. G. Savva, P. Germain, M. Grimaldi, A. Boulahtouf, H.-S. Kwong, J. Bous, A. Ancelin, C. Bechara, A. Barducci, P. Balaguer, W. Bourguet

The paper presents a cryo-EM structure of the AHR complex bound to a ligand, revealing structural details of its activation mechanism and ligand-binding specificity.

bioRxiv · May 17, 2022Biochemistry

In vitro evolution predicts emerging CoV-2 mutations with high affinity for ACE2 and cross-species binding

N. Bate, C. G. Savva, P. C. Moody, E. A. Brown, J. K. Ball, J. W. Schwabe, J. Sale, N. Brindle

The paper uses in vitro evolution to identify CoV-2 mutations that enhance ACE2 binding and cross-species transmission, finding mutations like Q498H and Q498R/N501Y that are emerging in variants like Omicron.

bioRxiv · Dec 23, 2021Biochemistry