A nucleation-and-growth model for the packaging of genome in linear virus-like particles: impact of multiple packaging signals
R. de Bruijn, R. P. Wielstra, C. Calcines Cruz, T. van Waveren, A. Hernandez-Garcia, P. van der Schoot
The paper develops a kinetic model to explain how packaging signals enhance DNA encapsulation by synthetic coat proteins, showing optimal kinetics when nucleation sites match the number of packaging signals.
bioRxiv · Feb 24, 2022Biophysics