Author

R. de Bruijn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Animal Behavior & Cognition· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:clustering· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Organism:human· 2

Frequent Co-Authors

J. Jonkers· 3 shared A. P. Drenth· 2 shared C. S. Brambillasca· 2 shared E. van der Burg· 2 shared J. Bhin· 2 shared A. Bertotti· 1 shared A. Bhattacharya· 1 shared A. C. O'Farrell· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersCancer Biology

J. Jonkers

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer

J. M. Houthuijzen, R. de Bruijn, E. van der Burg, A. P. Drenth, E. Wientjens, T. Filipovic, E. Bullock, C. S. Brambillasca, M. Nieuwland, I. de Rink, F. van Diepen, S. Klarenbeek, R. Kerkhoven, V. Brunton, C. L. G. J. Scheele, , J. Jonkers

The paper identifies CD26-negative and CD26-positive tissue-resident fibroblasts as sources of distinct CAF subpopulations in breast cancer through single-cell transcriptomics and functional assays.

bioRxiv · Sep 27, 2022 · PreprintCancer Biology

Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors

J. Bhin, M. Paes Dias, E. Gogola, F. Rolfs, S. R. Piersma, R. de Bruijn, J. de Ruiter, B. van den Broek, A. Duarte, W. Sol, I. van der Heijden, L. Bakker, T. S. Kaiponen, C. Lieftink, B. Morris, , J. Jonkers

bioRxiv · Sep 7, 2022Cancer Biology

A nucleation-and-growth model for the packaging of genome in linear virus-like particles: impact of multiple packaging signals

R. de Bruijn, R. P. Wielstra, C. Calcines Cruz, T. van Waveren, A. Hernandez-Garcia, P. van der Schoot

The paper develops a kinetic model to explain how packaging signals enhance DNA encapsulation by synthetic coat proteins, showing optimal kinetics when nucleation sites match the number of packaging signals.

bioRxiv · Feb 24, 2022Biophysics

Brain transcriptomic changes in Japanese quail reveal roles for neurotensin and urocortin 3 in avian parental care

P. C. Lopes, R. de Bruijn

The paper identifies neurotensin and urocortin 3 as genes involved in avian parental care in Japanese quail through transcriptomic analysis of brain regions.

Scientific Reports · Jul 29, 2021Peer-reviewedAnimal Behavior & Cognition

MYC promotes immune-suppression in TNBC via inhibition of IFN signaling

D. Zimmerli, C. S. Brambillasca, F. Talens, J. Bhin, A. Bhattacharya, S. E. P. Joosten, A. Moises da Silva, M. D. Wellenstein, K. Kersten, M. de Boo, M. Roorda, L. Henneman, R. de Bruijn, S. Annunziato, E. van der Burg, , J. Jonkers

This study shows MYC overexpression in TNBC reduces immune cell infiltration and interferon signaling, contributing to immune evasion and poor response to immunotherapy.

bioRxiv · Feb 24, 2021 · PreprintCancer Biology

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

X. Y. Woo, J. Giordano, A. Srivastava, Z.-M. Zhao, M. W. Lloyd, R. de Bruijn, Y.-S. Suh, R. Patidar, L. Chen, S. Scherer, M. Bailey, C.-H. Yang, E. Cortes-Sanchez, Y. Xi, J. Wang, , B. E Welm

This study shows that copy number profiles are conserved in patient-derived xenografts (PDXs) through engraftment and passaging, indicating minimal impact from the mouse host on tumor evolution.

bioRxiv · Dec 3, 2019Cancer Biology