Author

C. Calcines Cruz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:protein structure· 1 Approach:statistical model· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

A. Hernandez Garcia· 1 shared A. Hernandez-Garcia· 1 shared I. J. FInkelstein· 1 shared P. van der Schoot· 1 shared R. de Bruijn· 1 shared R. P. Wielstra· 1 shared T. van Waveren· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 11 mutual co-author links

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1 shared paperBioengineering

A. Hernandez Garcia

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2 papers

Recent·Most cited

BiophysicsbioRxivFeb 24, 2022

A nucleation-and-growth model for the packaging of genome in linear virus-like particles: impact of multiple packaging signals

R. de Bruijn, R. P. Wielstra, C. Calcines Cruz…·P. van der Schoot

The paper develops a kinetic model to explain how packaging signals enhance DNA encapsulation by synthetic coat proteins, showing optimal kinetics when nucleation sites match the number of packaging signals.

DOI 10.1016/j.bpj.2022.05.040

DNA methylationstatistical model

𝕏 PostBluesky

BioengineeringbioRxivOct 17, 2020

CRISPR-guided programmable self-assembly of artificial virus-like nucleocapsids

C. Calcines Cruz, I. J. FInkelstein, A. Hernandez Garcia

This paper uses CRISPR-Cas12a to direct the self-assembly of synthetic polypeptides into virus-like particles on specific DNA templates, enabling efficient and programmable DNA encapsidation.

DOI 10.1021/acs.nanolett.0c04640

protein structureDNA methylation

𝕏 PostBluesky