Hepatitis D virus infection of stem cell-derived hepatocytes triggers an IFN- and NFkB-based innate immune response unable to clear infection.
F. Lange, J. Garn, H. Anagho, T. von Hahn, T. Pietschmann, A. Carpentier
This paper shows that HDV infects stem cell-derived hepatocytes via NTCP and triggers an IFN and NFkB innate response that fails to clear the infection.
bioRxiv · Aug 11, 2022 · PreprintImmunology