ACPA-IgG variable domain glycosylation increases before the onset of rheumatoid arthritis and stabilizes thereafter; a cross-sectional study encompassing over 1500 samples
T. Kissel, L. Hafkenscheid, T. J. van Wesemael, M. Tamai, S.-y. Kawashiri, A. Kawakami, H. El-Gabalawy, D. van Schaardenburg, S. Rantapaa Dahlqvist, M. Wuhrer, A. H. M. van der Helm-van Mil, R. Allaart, D. van der Woude, H. U. Scherer, R. E. M. Toes, T. W. J. Huizinga
This study shows ACPA-IgG variable domain glycosylation increases before rheumatoid arthritis onset and stabilizes later, with lower levels at onset correlating with drug-free remission.
bioRxiv · Nov 5, 2021Immunology