M. Wuhrer

Tumor-expressed SPPL3 supports innate anti-tumor immune responses.

This study shows that SPPL3 in tumor cells affects innate immune responses by modulating nsGSLs, reducing susceptibility to neutrophils, NK cells, and γδ T cells.

Fc proteoforms of ACPA IgG discriminate autoimmune responses in plasma and synovial fluid of rheumatoid arthritis patients and associate with disease activity

The paper identifies Fc proteoforms of ACPA IgG that distinguish autoimmune responses in RA patients and correlate with disease activity.

CslA and GlxA from Streptomyces lividans form a functional cellulose synthase complex

This paper shows that CslA and GlxA from Streptomyces lividans form a functional cellulose synthase complex capable of synthesizing cellulose in vitro.

The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylatedIgG1 in naive but not antigen-experienced vaccinees

The paper examines afucosylated IgG1 responses after BNT162b2 vaccination, finding transient responses in naive individuals that correlate with second-dose antibody levels.

ACPA-IgG variable domain glycosylation increases before the onset of rheumatoid arthritis and stabilizes thereafter; a cross-sectional study encompassing over 1500 samples

This study shows ACPA-IgG variable domain glycosylation increases before rheumatoid arthritis onset and stabilizes later, with lower levels at onset correlating with drug-free remission.

Dissection of N-, O- and glycosphingolipid glycosylation changes in PaTu-S pancreatic adenocarcinoma cells upon TGF-β challenge

This study examines how TGF-β affects glycosylation patterns in pancreatic cancer cells, identifying N-glycome changes linked to SOX4 expression and SMAD4 deficiency.

Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination

The paper shows that natural infection with Plasmodium falciparum induces afucosylated PfEMP1-specific IgG, while subunit vaccination produces fully fucosylated IgG.

Structural and functional characterization of SARS-CoV-2 RBD domains produced in mammalian cells

This study characterizes SARS-CoV-2 RBDs produced in CHO and HEK293 cells, revealing distinct glycosylation patterns and confirming O-glycosylation at T323, with comparable functional binding properties.

The SPPL3-defined glycosphingolipid repertoire regulates immune responses by improving HLA class I access

The paper identifies a glycosphingolipid (GSL) signature that inhibits HLA-I antigen presentation and shows its reversal by clinically approved drugs.

Functional monovalency amplifies the pathogenicity of anti-MuSK IgG4 in myasthenia gravis

This study shows that monovalent anti-MuSK IgG4 antibodies enhance pathogenicity in myasthenia gravis compared to their bivalent form.

Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses

Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients induces hyper-inflammatory responses in macrophages, leading to endothelial barrier breakdown and microvascular thrombosis.

Afucosylated immunoglobulin G responses are a hallmark of enveloped virus infections and show an exacerbated phenotype in COVID-19

The paper shows that afucosylated IgG responses are common in enveloped virus infections and are more severe in COVID-19, with implications for immune response and pathology.

Site-specific glycosylation mapping of Fc gamma receptor IIIb from neutrophils of health donors

This study maps glycosylation sites of Fc gamma receptor IIIb from neutrophils using LC-MS/MS and identifies donor allotype differences.

Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown

The paper identifies endo-acting O-glycanases in gut bacteria that initiate mucin breakdown, challenging the current model of exo-acting glycosidases.

Natural killer cell activation by respiratory syncytial virus-specific antibodies is decreased in infants with severe respiratory infections and correlates with Fc-glycosylation

The paper examines how RSV-specific antibodies from infants with severe respiratory infections activate NK cells and links this to Fc-glycosylation, finding reduced activation in infected infants.