IL8 Drives an Elaborate Signal Transduction Process for CD38 to Produce NAADP from NAAD and NADP+ in Endolysosomes to Effect Cell Migration
T.-S. Nam, D.-R. Park, S.-Y. Rah, T.-G. Woo, H. T. Chung, C. Brenner, U.-H. Kim
The paper reveals how IL8 triggers a signaling pathway that enables CD38 to produce NAADP in endolysosomes, driving calcium signaling and cell migration.
bioRxiv · Mar 24, 2020Cell Biology