Structures of the PKA RIα holoenzyme with the FLHCC driver J-PKAcα or wild type PKAcα
B. Cao, T.-W. Lu, J. Martinez Fiesco, M. Tomasini, L. Fan, S. Simon, S. Taylor, P. Zhang
This paper reports the crystal structures of J-PKAc fusion and wild-type PKA holoenzymes, revealing structural differences and conformational dynamics that may impact their function in FLHCC.
bioRxiv · Dec 22, 2018Biochemistry