L. Fan

APOE Impacts Lipid Trafficking in Retinal Pigment Epithelium Cells

This study investigates how APOE variants affect lipid trafficking in RPE cells, finding that APOE knockout and APOE2-expressing cells show lipid transport deficits, while APOE4-expressing cells upregulate APOE in response to lipid challenges.

HKDC1 Promotes Liver Cancer Stemness Under Hypoxia via Stabilizing β-Catenin

This study identifies HKDC1 as a prometastatic enzyme in liver cancer that stabilizes β-catenin under hypoxia, enhancing cancer stemness.

Stimulation Effects Mapping for Optimizing Coil Placement for Transcranial Magnetic Stimulation

This paper introduces a framework for optimal TMS coil placement without segmentation or meshing, validated across multiple datasets showing consistent results.

The 3D ultrastructural morphology of a marine ammonia-oxidizing archaeon

This study uses cryo-ET and STEM-EDS to reveal the ultrastructural morphology and elemental composition of Nitrosopumilus maritimus SCM1, identifying two types of storage granules.

Landscape and functional repertoires of long noncoding RNAs in the pan-cancer tumor microenvironment using single-nucleus total RNA sequencing

The paper maps lncRNA landscapes across ten cancer types using single-nucleus RNA sequencing and identifies cell type-specific lncRNA-mRNA pairs and regulatory networks.

Large-scale lensless microscopy with fast acquisition and region-wise focusing

This paper develops a fast acquisition and region-wise focusing strategy for lensless microscopy, achieving high-resolution imaging of biological samples with reduced acquisition and reconstruction times.

Monocyte production of C1q potentiates CD8+ T cell effector function following respiratory viral infection

This study shows that monocyte-produced C1q enhances CD8+ T cell function during respiratory viral infections, as demonstrated in mice and human samples.

Exploring Urban Street Green Perception from the Perspective of Combining GVI and NDVI: A Case Study of Zhongshan City, Guangdong Province

This study combines GVI and NDVI to analyze urban street greening in Zhongshan City, finding strong correlation and scale sensitivity, and proposes optimization strategies.

A syntelog-based pan-genome provides insights into rice domestication and de-domestication

This paper constructs a syntelog-based pan-genome of rice using long-read sequencing to study domestication and de-domestication, identifying introgression events and domestication genes.

Ribonucleotide Reductase Subunit Switching in Hepatoblastoma Drug Response and Relapse

This study identifies RRM2 and RRM2B as key players in hepatoblastoma progression and drug response, showing their dynamic switching and impact on relapse.

Spatiotemporal Dynamics of Vcam1 Regulates Cholangiocarcinoma Mass Expansion and Tumor Dissemination under Growth-suppressive Peritumoral Myofibroblasts

This study shows that Vcam1 expression in cholangiocarcinoma cells is regulated by peritumoral myofibroblasts, promoting tumor dissemination while suppressing growth.

Structural basis for BIRC6 to balance apoptosis and autophagy

This study reveals the structural basis of BIRC6's role in balancing apoptosis and autophagy by showing its dimeric structure and interactions with Smac/DIABLO, caspase 3, HtrA2, and LC3.

Gene inversion triggered origination of brackish archaeal heterotrophs in the aftermath of the Cryogenian Snowball Earth

The paper traces the evolutionary origin of brackish archaea, showing gene rearrangements enabled their adaptation to coastal environments after the Cryogenian Snowball Earth.

Targeted Protein Degradation via Nanoparticles

This paper introduces a generic nanoparticle-based method for targeted protein degradation that avoids case-by-case design and enables degradation of both intracellular and extracellular targets.

Arabidopsis AAR2, a conserved splicing factor in eukaryotes, acts in microRNA biogenesis

This study identifies Arabidopsis AAR2 as a conserved splicing factor that also promotes miRNA biogenesis by interacting with HYL1 and regulating its dephosphorylation.

Reduced antigenicity of Omicron lowers host serologic response

The paper investigates reduced antigenicity of the Omicron variant, showing it evades antibodies and lowers serologic response, with implications for vaccine development.

Horizontal Transfers Lead to the Birth of Momilactone Biosynthetic Gene Clusters in Grass

This study shows that horizontal gene transfer created momilactone biosynthetic gene clusters in grasses, with subsequent gene recruitment and loss shaping their evolution.

Horizontal Transfer and Evolution of the Biosynthetic Gene Cluster for Benzoxazinoid

This study identifies horizontal transfer of a biosynthetic gene cluster for benzoxazinoids among grasses, revealing evolutionary mechanisms and selection pressures.

Regnase-1 deficiency restrains Klebsiella pneumoniae infection by regulation of a Type I interferon response

This study shows that Regnase-1 deficiency increases resistance to Klebsiella pneumoniae infection by enhancing Type I interferon responses, despite not affecting bacterial clearance or pro-inflammatory cytokine expression.

A Developmentally Prometastatic Niche to Hepatoblastoma in Neonatal Liver mediated by the Cxcl1/Cxcr2 Axis

This study identifies a neonatal liver niche that promotes hepatoblastoma metastasis via the Cxcl1/Cxcr2 axis, showing increased tumor aggressiveness and hypoxia in early postnatal models.

Isolation, identification and molecular characterization of Aeromonas spp. from farmed loach (Misgurnus anguillicaudatus)

This study identifies and characterizes Aeromonas species in farmed loaches from China, finding high prevalence of A. veronii and resistance to multiple antibiotics.

Spermidine dampens inflammation by directly inhibiting Th17 cytokine production through a PRDX1 associated antioxidant pathway

This study shows spermidine directly inhibits Th17 cytokine production via PRDX1-dependent antioxidant activity, reducing lung inflammation in mouse models.

Enhanced soil quality after forest conversion to vegetable cropland and tea plantation has contrasting effects on soil microbial structure and functions

This study examines how soil quality changes after forest conversion to vegetable cropland and tea plantations, showing contrasting effects on microbial community structure and functions.

Microtubules Promote the Non-cell Autonomy of MicroRNAs by Inhibiting their Cytoplasmic Loading into ARGONAUTE1 in Arabidopsis

The paper shows that microtubules inhibit miR165/6 loading into AGO1 in the cytoplasm, enabling its non-cell autonomous movement in Arabidopsis roots.

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1

This study reveals how HAP40 orchestrates HTT structure, affecting its interaction with polyglutamine-expanded exon 1, providing insights into Huntington's disease mechanisms.

Genotyping-by-sequencing-based identification of Arabidopsis pattern recognition receptor RLP32 recognizing proteobacterial translation initiation factor IF1

The paper identifies RLP32 as the Arabidopsis receptor for the bacterial pattern IF1, revealing its role in PTI and resistance to Pseudomonas syringae.

Paradoxical Roles of Peritumoral Myofibroblasts in Intrahepatic Cholangiocarcinoma Growth and Metastasis

This study shows peritumoral myofibroblasts suppress iCCA growth but promote metastasis through Vcam1-dependent mechanisms.

Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer

The paper uses single-cell RNA sequencing to show neuroendocrine prostate cancer cells originate from luminal-like cells, not basal cells, and identifies associated gene signatures.

Gold nanorod based delivery system could bring about superior therapy effect of Ramucirumab through direct cytotoxicity to cancer cell mediated by differential regulation of phagocytosis in gastric cancer cell

This paper demonstrates that gold nanorod-based delivery of Ramucirumab enhances cytotoxicity in gastric cancer cells through differential regulation of phagocytosis and Fcγ receptor expression.

Anomalous phylogenetic behavior of ribosomal proteins in metagenome assembled genomes

The paper shows that Asgard and CPR metagenome assembled genomes (MAGs) fail to meet basic phylogenetic criteria due to their anomalous ribosomal protein evolutionary histories, suggesting they are binning artifacts.