Loss of PIKfyve in Rod Photoreceptors and RPE Cells Leads to Endolysosomal Dysfunction and Retinal Degeneration
Ammaji Rajala, Larissa J Trevino, Thamaraiselvi Saravanan, Tabitha Black, Akbar M. Bhat, Tuan Ngo, Mark Eminhizer, Jianhai Du, Visvanathan Ramamurthy, Raju V. S. Rajala
The paper identifies PIKfyve as critical for endolysosomal function in photoreceptors and RPE cells, showing its loss leads to retinal degeneration and metabolic disturbances.
bioRxiv · Sep 15, 2025 · PreprintNeuroscience