Jianhai Du

This study identifies age-related proteomic and metabolic changes in the retina and RPE/Cho of mice, revealing tissue-specific and age-dependent shifts in metabolic pathways.

This study identifies metabolic changes in cone-dominant and cone-degenerating retinas, revealing key metabolites associated with cone abundance and metabolic vulnerabilities in retinal degeneration.

This study identifies metabolic differences between regions and tissues in the human retina and RPE/choroid using targeted metabolomics.

The paper maps the TRiC/CCT interactome in mouse photoreceptors and identifies its role in energy metabolism and neurodegeneration.

This study examines how different nutrient microenvironments affect RPE cell phenotype, function, and metabolism in iPSC and fetal RPE, identifying key metabolic shifts and phenotypic changes.

This study identifies early proteomic and metabolic changes in liver and eye tissues of OAT-deficient mice, revealing tissue-specific impacts of OAT deficiency.

This study identifies early proteomic changes in the retina and brain of 3xTg-AD mice, revealing shared and tissue-specific metabolic and transport dysregulation linked to Alzheimer's disease.

This study investigates the role of alanine transaminase (ALT) in human neural retina metabolism, showing its involvement in carbon/nitrogen flux and redox balance, with potential therapeutic implications for retinal diseases.

This study quantifies TCA cycle intermediates in mouse ocular tissues to reveal tissue- and sex-specific mitochondrial metabolism and diurnal variations.

The paper identifies PIKfyve as critical for endolysosomal function in photoreceptors and RPE cells, showing its loss leads to retinal degeneration and metabolic disturbances.

This study shows gene therapy can restore cone function and structure in a mouse model of blue cone monochromacy with the C203R mutation.

The paper identifies differences in stress response and function between macular and peripheral Muller cells, linking these differences to vulnerability to degenerative diseases.

This study identifies proline metabolism, specifically proline hydroxylation via P4HA1, as a driver of subretinal fibrosis in nAMD and shows that P4HA1 inhibition reduces fibrosis in mouse models.

This study identifies nutrient utilization differences between healthy and diseased human RPE cells, showing reduced metabolic flexibility in SFD RPE and the impact of differentiation on nutrient use.

This study shows that NMNAT1 deletion in developing murine retina causes severe photoreceptor and inner retinal neuron degeneration through multiple cell death pathways and metabolic disruptions.

The paper identifies metabolic differences between mouse and human retinas, cones vs. rods, macula vs. periphery, and retina vs. RPE, highlighting distinct metabolic pathways and nutrient exchange.

This study shows that AMPK regulates retinal metabolism and that its loss leads to photoreceptor and RPE cell degeneration.