Mark Eminhizer

This study identifies metabolic changes in cone-dominant and cone-degenerating retinas, revealing key metabolites associated with cone abundance and metabolic vulnerabilities in retinal degeneration.

The paper maps the TRiC/CCT interactome in mouse photoreceptors and identifies its role in energy metabolism and neurodegeneration.

This study examines how different nutrient microenvironments affect RPE cell phenotype, function, and metabolism in iPSC and fetal RPE, identifying key metabolic shifts and phenotypic changes.

This study quantifies TCA cycle intermediates in mouse ocular tissues to reveal tissue- and sex-specific mitochondrial metabolism and diurnal variations.

The paper identifies PIKfyve as critical for endolysosomal function in photoreceptors and RPE cells, showing its loss leads to retinal degeneration and metabolic disturbances.

This study identifies proline metabolism, specifically proline hydroxylation via P4HA1, as a driver of subretinal fibrosis in nAMD and shows that P4HA1 inhibition reduces fibrosis in mouse models.

This study identifies nutrient utilization differences between healthy and diseased human RPE cells, showing reduced metabolic flexibility in SFD RPE and the impact of differentiation on nutrient use.