Human meningiomas arise from developmental meningeal mosaicism
Young Soo Chung, Hye Joung Cho, T.H. Kim, Se Hoon Kim, Taek Chung, Seonah Choi, Tae Hoon Roh, J I Moon, Eui Hyun Kim, Chang Kyu Lee, Dong Ah Shin, Seong Yi, Yoon Ha, Keung Nyun Kim, Jong Hee Chang, , Sangwoo Kim
This study identifies developmental meningeal mosaicism as the origin of human meningiomas, showing that driver mutations are present in phenotypically normal meninges and shared across tumors.
bioRxiv · Jun 16, 2026 · PreprintCancer Biology