Yoon Ha

TRANsCre-DIONE transdifferentiates scar-forming reactive astrocytes into functional motor neurons

This paper describes a method to convert reactive astrocytes into functional motor neurons with high efficiency and specificity using TRANsCre-DIONE, leading to improved motor recovery in spinal cord injury.

Human meningiomas arise from developmental meningeal mosaicism

This study identifies developmental meningeal mosaicism as the origin of human meningiomas, showing that driver mutations are present in phenotypically normal meninges and shared across tumors.

Disruption of the hypothalamic orexin system links SARS-CoV-2 infection to persistent cortical neuronal pathology

This study shows SARS-CoV-2 causes lasting cortical neuronal injury and hypothalamic orexin dysfunction, linking it to Long COVID neurological symptoms.

Astrocytic MAOB-GABA axis as a molecular brake on repair following spinal cord injury

This study identifies the astrocytic MAOB-GABA axis as a brake on spinal cord injury repair and shows that the inhibitor KDS2010 promotes recovery in animal models and has a safe profile in humans.