Adaptive Laboratory Evolution (ALE) enables carbon-negative mixotrophic fermentation and enhanced chain elongation in Clostridium sp. JS66
Ji Myeong Kim, Taekwan Moon, Jung Ho Ahn, Ja Kyong Ko, Gyeongtaek Gong, Jae Yong Ryu, Sung Ok Han, Min‐Kyu Oh, Youngsoon Um
This study evolves Clostridium sp. JS66 to enhance CO2 reassimilation and chain elongation, achieving carbon-negative fermentation of glucose to hexanoic acid.
Bioresource Technology · Sep 9, 2026Peer-reviewedBioengineering