Sequence-intrinsic barriers define a class of translation-restricted uORFs in the human genome
Hinata Hashimoto, Taichi Akase, Hikaru Kurasawa, Shohei Kitano, Yasunori Aizawa
The paper identifies translation-restricted uORFs in the human genome that act as sequence-intrinsic barriers to protein production, showing they are under purifying selection as cis-regulatory elements.
bioRxiv · Aug 21, 2026 · PreprintGenetics