Yasunori Aizawa

The paper identifies translation-restricted uORFs in the human genome that act as sequence-intrinsic barriers to protein production, showing they are under purifying selection as cis-regulatory elements.

This paper synthesizes the largest eukaryotic yeast chromosome, synIV, and investigates how its 3D structure affects gene regulation and transcription.

The paper characterizes floating segments in proteins, finding they contain coil structures, interact with polypeptides and polynucleotides, and have specific amino acid preferences.

The paper identifies a uORF in mammalian mRNAs that functions independently of its downstream anORF, challenging the monocistronic gene model.