Developmental Downregulation of LIS1 Expression Limits Axonal Extension and Allows Axon Pruning
Kanako Kumamoto, Tokuichi Iguchi, Ryuichi Ishida, Takuya Uemura, Makoto Sato, Shinji Hirotsune
This study shows that developmental downregulation of LIS1 limits axonal extension and allows axon pruning, which is essential for neuronal circuit formation but hinders nerve regeneration.
Biology Open · Jan 1, 2017Peer-reviewedNeuroscience