Evolution of binding preferences among whole-genome duplicated transcription factors
Tamar Gera, Felix Jonas, Roye More, Naama Barkai
The paper examines how duplicated transcription factors in budding yeast evolve binding preferences, finding that most divergence occurs outside DNA binding domains and that new targets are acquired by the least conserved paralog.
eLife · Jan 21, 2022Peer-reviewedGenomics