Felix Jonas

The paper challenges the model of transcription factor binding cooperativity by showing limited effects of motif combinatorics in yeast using a novel massively parallel binding assay.

This study identifies Yet3 as a protein that recruits sterol biosynthesis enzymes to ER contact sites, enabling on-demand sterol production and influencing organellar structure and function.

The paper uses a histone exchange sensor to study variant-specific dynamics of histone incorporation and exchange in mouse embryonic stem cells, revealing variant-specific associations with transcription and Polycomb binding.

The paper uses a histone exchange sensor to show Rtt109 promotes H3 replacement ahead of the replication fork in budding yeast, independent of H3K56 acetylation.

The paper examines how duplicated transcription factors in budding yeast evolve binding preferences, finding that most divergence occurs outside DNA binding domains and that new targets are acquired by the least conserved paralog.

The paper investigates how morphogen gradients, specifically the Dorsal protein gradient in Drosophila embryos, generate graded responses through transcriptional and translational mechanisms.